Tap to zoomWhat Is Peyronie's Plaque? Causes, Symptoms, and Treatment
Peyronie's plaque is a lesion that forms in the outer layer of the corpora cavernosa, or on the internal penile bodies under the skin. It is an inflammatory thickening with excess collagen and connective tissue that reduces penile flexibility.
- Published on
- June 26, 2026
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- 5 min read
- Last updated
- Updated: June 26, 2026
Old plaque It is a common tissue disease first introduced in 1743 by Mr. Pyroni. It is an old plate that forms in the cave objects or so on the internal objects of the skin under the skin, this plaque is an inflammatory thickening that is combined with the production of collagen and concoction tissue and reduces the flexibility of the penis, and eventually the calcium deposit along with fibrosis and the stiffness of that area occurs as a result can be tilted or alted into the surface of the clock.
This disease is likely caused by repeated penis vascular injuries that cause inflammation leaks from inside the penis.
Although its inherited transfer is also likely, its congenital form is also seen and some research suggests that low testosterone levels (male hormone) can cause it.

The cause of aging plaque disease
The exact prevalence of the disease is not clear because some men never visit the doctor due to embarrassment, but according to current research, it has been between 3 and 9 percent, which generally occurs in the 50s, in a study of people who visit age 50 and young adults, generally have a greater number of plaques and diabetes.
Also hypertension, increased blood fat, heart disease UnconditionedSmoking and drinking too much alcohol is associated with it, though the way these plaques are still unclear.
symptoms of aging disease
When the disease first shows itself, it is usually pain during erection and sexual aversion, and a plaque loss occurs inside the penis, its inflammatory phase usually ends in 18 to 24 months, followed by a plaque along with calcium barcobage and penis drainage.
How to identify Old plaque disease
In this case, the length of the penis is measured at a false level from the rule to its tip, the size of the plaque and its crookedness in an erection mode, and the amount of diversion can be provided to the doctor by the photos the patient has made at home.
The disease is based on the current description of the patient and the examination of the doctor, an ultrasound for the disease is not routinely recommended since it is dependent on the operator and the diagnostic error is likely to perform a alt-color ultrasound to evaluate cardiovascular disorders.
Research has shown that the disease is a self-limiting disease that has an active phase first, eventually reaching the maturity stage and forming plaque. Since the process is long and different phases have a detailed assessment of the effectiveness of medications a bit difficult.
Learn more.” Treatment of the penis plan The act of vasectomy
Treatment of old plaque
TRADITIONAL TREATMENT METHODS ARE GENERALLY DIVIDED IN THREE GROUPS OF ORAL, INJECTED OR TOPICAL TREATMENT AND ALTERNATIVE TISSUE TRANSPLANT SURGERY. THE PROBLEM THAT EXISTS IS THAT THERE IS NO DEFINITIVE TREATMENT FOR THIS CONDITION SO FAR, AND DRUG TREATMENT DOES NOT HAVE ENOUGH EFFECT ON TREATING IT. SURGERY ALSO RISKS SEXUAL DISABILITY. TREATMENTS WITH ESWT WAVES HAVE NOT WORKED EFFECTIVELY. ZAFLEX INJECTIONS HAVE BEEN PARTLY AN EFFECT ON THIS DISEASE, WHICH IS NOT AVAILABLE IN THE MARKET.
Before deciding for surgery or infusion of medications, the disease should pass for several months to reach the maturity stage or end of the active phase, since the standard and definitive procedure for its treatment is not yet specified, it is recommended that a combination of oral treatment, treatment within the lesions along with small surgical techniques for low-to-medium patients. In the event of mental and psychological problems and referral depression to your doctor’s psyche, it will cause patients to start injury.

1) Food medications
VARIOUS MEDICATIONS FOR THIS DISEASE HAVE BEEN USED SINCE ANCIENT TIMES, SUCH AS PARAAMINES, VITAMIN E, WHOLE SHIIN, KAROLIN, TAMOOXY FAN AND PENOXIN, IN THE LATEST RESEARCH THAT THE EFFECT OF THESE DRUGS IN TREATING THE DISEASE IS NOT SIGNIFICANT, AND MEDICATIONS SUCH AS VITAMIN E, CARNITINE, TAMOXI, FAN, TECHNOLOGY Petaba powderCarlytin and penoxin are no longer recommended in Europe.
The drug in the UK is currently licensed for the oral treatment of the Pyroni plaque, Paramatazine. In fact, paranoids may reduce the size of the penis, relieve pain, and prevent the process and progress, only parathomans in the UK have been licensed as oral treatment.
potassium para-aminobenzoate is a drug that is known to be effective by the U.S. FDA. You will see a list of effective medications in older therapy:
Vitamin E
Potaba: According to the evidence of this drug in taking a 12-month period in reducing pain, reducing plaque size and preventing effective curvature progress, it has not underestimated the curvature of the penis.
Tamoxifen
Colchicine
Acetyl esters of carnitine
Pentoxifylline
• topical and injection treatments
One of the treatments that can help to some extent improve this condition is to inject medications such as vapamil with small needles into plaque. Usually, 6 injections take place at 2 weeks. There is no very strong evidence about the effectiveness of medications such as inter-breeds and collagens Since corticosteroids or similar steroids can increase inflammation in this area, it is recommended to ban them. We call a number of samples in the plaque:
Steroids
Verapam
Clostridial collagenase
Interferon
Verapa is a drug that can improve tilt and reduce plaque size in its long-term consumption (9 months and more), but there is no evidence of whether the drug can be absorbed through the skin and infiltrated into the internal layers of the penis. For example, pay attention to topical treatments that have been named after.
Verapamil
Iontophoresis
Extracorporeal shock wave lithotripsy (SWL)
Traction devices
Vacuum devices

3 old plaque surgery
Surgery-free procedures in treating older plaque reduce the pain of erection, but in a few cases they will lead to the smoothing of the patient’s penis. The goal of surgery is to modify the deviation and straighten the penis. Surgery is done when the disease enters a fixed phase (at least for 3 months) and is sometimes recommended to take at least 6 to 12 months after the onset of the disease. In general, two types of surgery are used in the restoration of the non- congenital penis curvature.
Shortening the convex side of the penis, which will result in penile shortening.
Use and link tissue and focus on the bottom part of the penis that will eventually make it bigger.
In cases where the patient has an erection disorder and the drug treatment is not effective, in addition to the curvature modification, it can also be placed for the prosthesis patient.
Choosing the surgical procedure is taken according to the patient’s conditions and by the doctor. Patient expectation, an erection status and animosity as well as the length of the penis are effective in this decision. It is best to speak to the patient before the procedure of the exact patients and to discuss their expectations and improve them after surgery and provide adequate explanations for the purpose and risks of surgery (the risk of shortening the length of the penis, the risk of tilting the penis, the probability of touching nodes and stitches by the skin after surgery) to the patient clearly and clearly explain the patient.
Surgery is done when the disease enters a fixed phase (at least for 3 months) and is sometimes recommended to take at least 6 to 12 months after the onset of the disease.

Different techniques in Pyroni plaque surgery
The first method is to remove the albodi layer: The method in which part of the tissue is cut and removed from the old plaque in the so-called niikatic acid layer and then the two edges of the deleted part are stitches in this method, usually the length of the penis is shortened and this method is used in patients who are abnormally normal and the pulsation is less than 60 degrees.
Second method (The method of Todd or China giving the Tonyka layer): Instead of cutting and removing this method, it is used to peel the subcutaneous layer of the penis or the Tonyka, which will also reduce the length of the penis.
Third method (to remove plaque and use graphite): This method is used in cases where altruism is more than 60 degrees.
The fourth method (to remove plaque and use an ultrasound) This method is more than 60 degrees and at the same time Sexual disability There is also the best option to remove plaque and use the prosthesis simultaneously.
Fifth method (using carbon dioxide laser) : In some plaques to reduce plaque thickness, this procedure can be used during surgery.
Physiotherapy
From the most effective and effective ways of treating old plaque, physical therapy. Physical therapy is usually pain-free for aging treatment and has no specific pain or complications. According to the patient’s sexual problem, the specialist selects one of the physical therapy methods. Shak Weio, Yotovroses, are similarly therapeutic, vacuum and ultrasounds, including these methods.
stretching
The use of external traction or organ deployment is a new technique that is being explored, new reviews have shown that this technique improves the length of the penis and improves its decouption and distortion.
vacuum machine
Empty devices will also help like the stretch method.
(ESWT)
In Shakutherapy, high-energy audio waves are applied to fibrous tissue by the device outside the penis. The number of treatment sessions is usually 4 to 6 sessions and for 20 minutes. It’s not enough research on the effectiveness of this type of treatment, although this treatment won’t cause significant damage to the patient, so various research is underway around the world and patients who like to choose this treatment can be cited.
Tips for Treatments Without Surgery of Pyroni disease
Non-surgical treatments are usually prescribed in patients who are in the primary phase and more acute patients should be surgical.
The tools and methods that create traction on the penis and vacuum can reduce the curvature and increase the length of the penis.
UV WAVES (ESWL) CAN REDUCE THE PAIN OF THE PENIS AND HAVE NO EFFECT ON THE REFORM OF THE CURVATURE AND PLAQUE TREATMENT.
15% can be somewhat effective in improving penis curvature and plaque size.
The injection of collagen totalitarians leads to reduced the angle of deviation, width and length of the penis.
Interferon injection can be effective in improving curvature, size and pain.
The final word
Pyroni plaque rarely resolves fully, research has shown that about 13 percent of patients experience relief or complete improvement of pain over time, half of patients with pre-processed disease and another half have a stable condition, and symptoms may range from a constant plaque to an erection with a crooked pain that leads to a patient’s avoidance of sex.
Since evidence shows that the impact of long-term treatment is inadequate, the effect of different therapeutic methods on the prognosis of the disease is not well known.
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