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Dr. Mahdi Ghazi Urology Clinic

Surgeon & specialist in kidney, urinary and genital tract

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Educational article

What Is Peyronie's Plaque? Causes, Symptoms, and Treatment

Peyronie's plaque is a lesion that forms in the outer layer of the corpora cavernosa, or on the internal penile bodies under the skin. It is an inflammatory thickening with excess collagen and connective tissue that reduces penile flexibility.

Published on
June 26, 2026
Reading time
5 min read
Last updated
Updated: June 26, 2026

Old plaque It is a common tissue disease first introduced in 1743 by Mr. Pyroni. It is an old plate that forms in the cave objects or so on the internal objects of the skin under the skin, this plaque is an inflammatory thickening that is combined with the production of collagen and concoction tissue and reduces the flexibility of the penis, and eventually the calcium deposit along with fibrosis and the stiffness of that area occurs as a result can be tilted or alted into the surface of the clock.

This disease is likely caused by repeated penis vascular injuries that cause inflammation leaks from inside the penis.

Although its inherited transfer is also likely, its congenital form is also seen and some research suggests that low testosterone levels (male hormone) can cause it.

بیماری پلاک پیرونی

The cause of aging plaque disease

The exact prevalence of the disease is not clear because some men never visit the doctor due to embarrassment, but according to current research, it has been between 3 and 9 percent, which generally occurs in the 50s, in a study of people who visit age 50 and young adults, generally have a greater number of plaques and diabetes.

Also hypertension, increased blood fat, heart disease UnconditionedSmoking and drinking too much alcohol is associated with it, though the way these plaques are still unclear.

symptoms of aging disease

When the disease first shows itself, it is usually pain during erection and sexual aversion, and a plaque loss occurs inside the penis, its inflammatory phase usually ends in 18 to 24 months, followed by a plaque along with calcium barcobage and penis drainage.

How to identify Old plaque disease

In this case, the length of the penis is measured at a false level from the rule to its tip, the size of the plaque and its crookedness in an erection mode, and the amount of diversion can be provided to the doctor by the photos the patient has made at home.

The disease is based on the current description of the patient and the examination of the doctor, an ultrasound for the disease is not routinely recommended since it is dependent on the operator and the diagnostic error is likely to perform a alt-color ultrasound to evaluate cardiovascular disorders.

Research has shown that the disease is a self-limiting disease that has an active phase first, eventually reaching the maturity stage and forming plaque. Since the process is long and different phases have a detailed assessment of the effectiveness of medications a bit difficult.

Learn more.” Treatment of the penis plan The act of vasectomy

Treatment of old plaque

TRADITIONAL TREATMENT METHODS ARE GENERALLY DIVIDED IN THREE GROUPS OF ORAL, INJECTED OR TOPICAL TREATMENT AND ALTERNATIVE TISSUE TRANSPLANT SURGERY. THE PROBLEM THAT EXISTS IS THAT THERE IS NO DEFINITIVE TREATMENT FOR THIS CONDITION SO FAR, AND DRUG TREATMENT DOES NOT HAVE ENOUGH EFFECT ON TREATING IT. SURGERY ALSO RISKS SEXUAL DISABILITY. TREATMENTS WITH ESWT WAVES HAVE NOT WORKED EFFECTIVELY. ZAFLEX INJECTIONS HAVE BEEN PARTLY AN EFFECT ON THIS DISEASE, WHICH IS NOT AVAILABLE IN THE MARKET.

Before deciding for surgery or infusion of medications, the disease should pass for several months to reach the maturity stage or end of the active phase, since the standard and definitive procedure for its treatment is not yet specified, it is recommended that a combination of oral treatment, treatment within the lesions along with small surgical techniques for low-to-medium patients. In the event of mental and psychological problems and referral depression to your doctor’s psyche, it will cause patients to start injury.

تماس با ما

1) Food medications

VARIOUS MEDICATIONS FOR THIS DISEASE HAVE BEEN USED SINCE ANCIENT TIMES, SUCH AS PARAAMINES, VITAMIN E, WHOLE SHIIN, KAROLIN, TAMOOXY FAN AND PENOXIN, IN THE LATEST RESEARCH THAT THE EFFECT OF THESE DRUGS IN TREATING THE DISEASE IS NOT SIGNIFICANT, AND MEDICATIONS SUCH AS VITAMIN E, CARNITINE, TAMOXI, FAN, TECHNOLOGY Petaba powderCarlytin and penoxin are no longer recommended in Europe.

The drug in the UK is currently licensed for the oral treatment of the Pyroni plaque, Paramatazine. In fact, paranoids may reduce the size of the penis, relieve pain, and prevent the process and progress, only parathomans in the UK have been licensed as oral treatment.

potassium para-aminobenzoate is a drug that is known to be effective by the U.S. FDA. You will see a list of effective medications in older therapy:

  • Vitamin E

  • Potaba: According to the evidence of this drug in taking a 12-month period in reducing pain, reducing plaque size and preventing effective curvature progress, it has not underestimated the curvature of the penis.

  • Tamoxifen

  • Colchicine

  • Acetyl esters of carnitine

  • Pentoxifylline

• topical and injection treatments

One of the treatments that can help to some extent improve this condition is to inject medications such as vapamil with small needles into plaque. Usually, 6 injections take place at 2 weeks. There is no very strong evidence about the effectiveness of medications such as inter-breeds and collagens Since corticosteroids or similar steroids can increase inflammation in this area, it is recommended to ban them. We call a number of samples in the plaque:

  • Steroids

  • Verapam

  • Clostridial collagenase

  • Interferon

Verapa is a drug that can improve tilt and reduce plaque size in its long-term consumption (9 months and more), but there is no evidence of whether the drug can be absorbed through the skin and infiltrated into the internal layers of the penis. For example, pay attention to topical treatments that have been named after.

  • Verapamil

  • Iontophoresis

  • Extracorporeal shock wave lithotripsy (SWL)

  • Traction devices

  • Vacuum devices

درمان پلاک پیرونی

3 old plaque surgery

Surgery-free procedures in treating older plaque reduce the pain of erection, but in a few cases they will lead to the smoothing of the patient’s penis. The goal of surgery is to modify the deviation and straighten the penis. Surgery is done when the disease enters a fixed phase (at least for 3 months) and is sometimes recommended to take at least 6 to 12 months after the onset of the disease. In general, two types of surgery are used in the restoration of the non- congenital penis curvature.

  1. Shortening the convex side of the penis, which will result in penile shortening.

  2. Use and link tissue and focus on the bottom part of the penis that will eventually make it bigger.

In cases where the patient has an erection disorder and the drug treatment is not effective, in addition to the curvature modification, it can also be placed for the prosthesis patient.

Choosing the surgical procedure is taken according to the patient’s conditions and by the doctor. Patient expectation, an erection status and animosity as well as the length of the penis are effective in this decision. It is best to speak to the patient before the procedure of the exact patients and to discuss their expectations and improve them after surgery and provide adequate explanations for the purpose and risks of surgery (the risk of shortening the length of the penis, the risk of tilting the penis, the probability of touching nodes and stitches by the skin after surgery) to the patient clearly and clearly explain the patient.

Surgery is done when the disease enters a fixed phase (at least for 3 months) and is sometimes recommended to take at least 6 to 12 months after the onset of the disease.

جراحی پلاک پیرونی

Different techniques in Pyroni plaque surgery

  • The first method is to remove the albodi layer: The method in which part of the tissue is cut and removed from the old plaque in the so-called niikatic acid layer and then the two edges of the deleted part are stitches in this method, usually the length of the penis is shortened and this method is used in patients who are abnormally normal and the pulsation is less than 60 degrees.

  • Second method (The method of Todd or China giving the Tonyka layer): Instead of cutting and removing this method, it is used to peel the subcutaneous layer of the penis or the Tonyka, which will also reduce the length of the penis.

  • Third method (to remove plaque and use graphite): This method is used in cases where altruism is more than 60 degrees.

  • The fourth method (to remove plaque and use an ultrasound) This method is more than 60 degrees and at the same time Sexual disability There is also the best option to remove plaque and use the prosthesis simultaneously.

  • Fifth method (using carbon dioxide laser) : In some plaques to reduce plaque thickness, this procedure can be used during surgery.

Physiotherapy

From the most effective and effective ways of treating old plaque, physical therapy. Physical therapy is usually pain-free for aging treatment and has no specific pain or complications. According to the patient’s sexual problem, the specialist selects one of the physical therapy methods. Shak Weio, Yotovroses, are similarly therapeutic, vacuum and ultrasounds, including these methods.

  • stretching

The use of external traction or organ deployment is a new technique that is being explored, new reviews have shown that this technique improves the length of the penis and improves its decouption and distortion.

  • vacuum machine

Empty devices will also help like the stretch method.

  • (ESWT)

In Shakutherapy, high-energy audio waves are applied to fibrous tissue by the device outside the penis. The number of treatment sessions is usually 4 to 6 sessions and for 20 minutes. It’s not enough research on the effectiveness of this type of treatment, although this treatment won’t cause significant damage to the patient, so various research is underway around the world and patients who like to choose this treatment can be cited.

Tips for Treatments Without Surgery of Pyroni disease

  1. Non-surgical treatments are usually prescribed in patients who are in the primary phase and more acute patients should be surgical.

  2. The tools and methods that create traction on the penis and vacuum can reduce the curvature and increase the length of the penis.

  3. UV WAVES (ESWL) CAN REDUCE THE PAIN OF THE PENIS AND HAVE NO EFFECT ON THE REFORM OF THE CURVATURE AND PLAQUE TREATMENT.

  4. 15% can be somewhat effective in improving penis curvature and plaque size.

  5. The injection of collagen totalitarians leads to reduced the angle of deviation, width and length of the penis.

  6. Interferon injection can be effective in improving curvature, size and pain.

The final word

Pyroni plaque rarely resolves fully, research has shown that about 13 percent of patients experience relief or complete improvement of pain over time, half of patients with pre-processed disease and another half have a stable condition, and symptoms may range from a constant plaque to an erection with a crooked pain that leads to a patient’s avoidance of sex.

Since evidence shows that the impact of long-term treatment is inadequate, the effect of different therapeutic methods on the prognosis of the disease is not well known.

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34 comments

  • ناشناس
    سلام آقای دکتر  من یک جوان 23 هستم و  حدود یک سال یک توده حس میکردم اما جدی نگرفتم و الان حدود یک ماهه متوجه شدم پلاک پیرونی دارم و زیر نظر هستم. من دانشجو هستم و هنور ازدواج نکردم و از این بابت خیلی نگران هستم! لطفا راهنمایی کنید برای درمان قطعی این بیماری باید چیکار کنم؟
  • مطب دکتر مهدی قاضی
    با سلام لطفا حضوری مراجعه بفرمایید تا سیر درمان توضیح داده شود.
  • ناشناس
    سلام ۴۵سال دارم دچارزودانزالی هستم وهمچنین چندسالیه که برای تغییرسایزآلت تناسلی قرص وکرمهای زیادی مصرف کردم اماهیچ نتیجه ای نگرفتم اعتمادبه نفسم راازدست دادم بطوریکه باهیچ کس نمیخوام ارتباط جنسی برقرارکنم لطفاراهنماییم کنیدممنون ازشما
  • ناشناس
    با سلام آلت من در حالت معمولی شبیه ساعت شنی است اما در حالت نعوظ آلت من کاملا صاف میشه مشکلش چیه
  • ناشناس
    با سلام و عرض ادب من یه مدتی خودارضایی می کردم اما الان خیلی وقته دیگه خودارضایی نمی کنم. آلت من در حالت عادی شبیه ساعت شنی است اما در حالت نعوظ کاملأ صاف میشه و دیگه مثل ساعت شنی نمی شود اما در حات عادی شبیه ساعت شنی است. آیا ممکنه مشکلی که واسه آلت من پیش آمده علتش خودارضایی باشه؟؟
  • مطب دکتر مهدی قاضی
    با سلام ، طبق این شرح حال، خیر نگران نباشید.
  • ناشناس
    پس مشکلی که واسه آلت من پیش آمده جدی نیست
  • مطب دکتر مهدی قاضی
    اگر نگران هستید بهتر است برای معاینه به متخصص اورولوژیست مراجعه کنید.
  • ناشناس
    آیا خودارضایی یکی از عوامل بیماری پیرونی است؟؟؟؟
  • ناشناس
    آیا خودارضایی یکی از عوامل بیماری پیرونی می باشد ؟؟؟؟
  • مطب دکتر مهدی قاضی
    با سلام خیر
  • ناشناس
    با سلام و عرض ادب خسته نباشید. آیا خودارضایی کردن باعث بیماری پیرونی می شود؟؟؟لطفاً توضیح دهید. ممنون و با تشکر فراوان.
  • ناشناس
    آیا خودارضایی کردن باعث بیماری پیرونی می شود ممنون میشم اگر توضیح بدهید. ممنون و با تشکر فراوان
  • ناشناس
    با سلام خسته نباشید می خواستم بپرسم آیا خودارضایی کردن باعث بیماری پیرونی می شود؟؟؟ لطفاً توضیح دهید. ممنون و با تشکر
  • ناشناس
    با سلام و درود خسته نباشید آیا خودارضایی کردن باعث بیماری پیرونی می شود؟؟؟ لطفاً توضیح دهید. ممنون و با تشکر فراوان
  • ناشناس
    با سلام من در ۴ سالگی ختنه شدم و لان ۱۵ سالمه آلتم شبیه ساعت شنی شده و در زیر آلتم یک توده وجود داره آیا این مشکلی که شرح دادم می تواند به دلیل ختنه اشتباه باشد؟؟؟؟؟ آیا این مشکلی که برای آلتم پیش آمده قابل درمان است؟؟؟؟
  • مطب دکتر مهدی قاضی
    سلام ، لازم است توسط یک ارولوژیست حضورا معاینه و بررسی شوید.
  • ناشناس
    سلام درمان پلاک چقدر هزینه دارد روش ۴و۵چون بیش از ۶۰درحه هست
  • ناشناس
    سلام دکتر من ۲۶ سالمه آلتم موقعه نعوظ قوس رو ب پایین داره ولی هیچ دردی یا توده ای رو آلتم نیست ایا بامصرف قرص پنتوکسی فیلین ۴۰۰ نتیجه ای برام حاصل میشه یا باید جراحی کنم
  • ناشناس
    سلام خسته نباشین این متن توی سونو گرافی یعنی چی بیماری خیلی پیشرفت کرده ایا خطر ناکه ؟ آیابا دارو قابل درمان هست تصویر پلاک پیرونیبه ابعاد ۵.۲میلیمتردر سطح دورسال روت پنیس دیده میشود
  • ناشناس
    سلام اقای دکتر من مشکل کجی الت و مقداری بعد از پایه باریک میشه مثل تصویر ساعت شنی مشکل نعوظ از مقداری بعد پایه رو شدید دارم ایا بعد جراهی کاملا مشکل کجی ونعوظ بر طرف میشه یا به مشکل سفت شدن برخورد میکنم جواب سنوگرافی بیماری پپرونی رو تشخیص دادن پلاک به قطر 6 میلیمر میباشد ممنون ازراهنمایی دکتر
  • ناشناس
    باسلام وآرزوی توفیق دکترمن ۴۰سالمه آلت تناسلی بنده مدت ۴روزاست که تورم شدیدکرده وددردی هم نداردلطفاکمکم کنید
  • rezgar
    سلام اقای دکتر خسته نباشید من پلا آلت دارم دکترم گفته امپول وراپامیل تهیه کنم که اصلا گیر نمیاد ایا با این امپول معالجه میشم
  • جمشید کمالی
    سلام آیا دستگاه فیزیوتراپی خانگی برای درمان پلاک پیرونی مفید است
  • ناشناس
    سلام من کجی آلت بیشتر از ۳۰ درجه دارم یه چند سالی هست که این مشکل رو دارم میخاستم بدونم چیکار کنم برم عمل کنم یا برم فیزیوتراپی نگرانم که نتونم ازدواج کنم به خاطر این مشکل
  • ناشناس
    سلام ببخشید خواستم نحود تزریق وراپامیل روی پلاک نمایش داده شود
  • کلینیک دکتر مهدی قاضی
    تزریق وراپامیل باید توسط متخصص اورولوژی انجام شود لطفا خودتان این کار را نکنید
  • کلینیک دکتر مهدی قاضی
    کجی آلت در صورتی که برای رابطه مشکل ایجاد کرده باشد قابل اصلاح است
  • مهران
    سلام .آیا ممکن است کجی آلت بدون وجود پلاک درونی ایجاد شود . مثلا بر اثر زخمی که براثر عوارض مصرف داروی گلورنتا بوجود آمده. بنده آلتم هنگام نعوظ قوس رو به پایین پیدا میکند . احساس میکنم سمت راست آلتم بر اثر زخم حادث شده بر اثر مصرف قرص گلورنتا خورده شده است و همین امر باعث عدم خونرسانی به آلت میشود و قوس ایجاد میشود .
  • دکتر مهدی قاضی
    سلام ,برای بررسی علت و درمان کجی آلت نیاز هست که به صورت حضوری معاینه شوید
  • دکتر مهدی قاضی
    خیر
  • دکتر مهدی قاضی
    جهت جلوگیری از پیشرفت و کجی آلت و درد باید درمان شروع شود
  • علی
    سلام دکتر گفته که تجمع کلسیم در انتهای آلت داری آیا این قابل درمان است داروها پنتوکسی ۵۰۰ قرص ال ارژنین ۵۰۰ پروسیال ۵ برام نوشته
  • دکتر مهدی قاضی
    روش های درمانی در مقاله شرح داده شده است.